Hypoxia Can Cause Stomach Ulcer

Alias ​​an ulcer wound on the surface of the stomach wall is not only due to increased gastric acid. Hypoxia, ie a decrease in blood oxygen levels, can also cause peptic ulcers. Fortunately, the body has the power of adaptation to cope with and heal the wound.Thus the results of the study Dr. Ari Fahrial SpPD Sham-KGEH (45) for a doctoral dissertation in Biomedical Sciences with the title "Development of Molecular Pathophysiology of Mucosal Lesions in Rats Gaster Chronic Systemic Hypoxia: Overview of Expression of Hypoxia Inducible Factor-1a, Heat Shock Factor, and Heat Shock Protein 70 ". The dissertation was defended in the trial examiner with Chairman Dr. Dr. Ratna Sitompul SpM (K), Dean of the Faculty of Medicine, University of Indonesia (Faculty of medicine); and Testing Team Leader Prof. Dr. Francis D Suyatna SPF (K) PhD, Professor of Pharmacology Faculty of medicine, Friday ( 15 / 7), with a passing grade 3.9.Act as a promoter, Prof. Dr. Aziz Rani SpPD-KGEH, Professor of Medicine Faculty of medicine, and cupping romotor Prof. Dr. Mohamad Sadikin DSc, Professor of Biochemistry Faculty of Medicine; and Dr. Dr. Septelia Inawati Wanandi, faculty member Doctoral Program Biomedical Sciences Faculty of medicine.According to Ari, who now serves Plh Head of the Division of Gastroenterology Department of Medicine Faculty of medicine, there is a balance of factors in gastric aggressive and defensive factors. Aggressive factor in the excess amount can cause damage to the gastric mucosa (stomach wall surfaces). Among other things, gastric acid, pepsin, bile reflux, nicotine (cigarettes), alcohol, nonsteroidal anti-inflammatory non-steroids, corticosteroids, Helicobacter pylori infection, stress, and ischemia (lack of blood in the body tissues). Defensive factors play a role maintaining the integrity of the surface of the stomach wall.Hypoxia can be caused by impaired cardiovascular system (heart and blood vessels), respiratory system (breathing, eg lung infection), or decreased oxygen supply, eg in enclosed spaces without good air circulation, or in the mountains. Systemic hypoxia causes constriction of blood vessels in the stomach wall, causing ischemia in the gastric wall, resulting in cell death and tissue wall of the stomach ulcer.Chronic systemic hypoxia (occurring in a long time) causes weight loss. This was due to an increase in leptin, a hormone related to appetite. Increased leptin causes decreased appetite. Increased leptin during hypoxia induced by HIF-1a. "The body has a reaction marked decrease in metabolic adaptation and energy savings," said Ari.Ari results in mice showed, in the course of time, the wound can heal itself. In the stomach, hypoxia increases hypoxia inducible factor (HIF-1) and heat shock factor (HSF-1). HSF-1 activates the heat shock protein (HSP), a protective protein.This study, said Ari, besides the opportunity to look for drugs that act for the treatment of peptic ulcers, also reminded the need for prevention of peptic ulcers in the conditions that cause chronic systemic hypoxia